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West Florissant, Mo. Explodes in Protest of Police Shooting, More Than 30 Arrests

West Florissant, Mo. Explodes in Protest of Police Shooting, More Than 30 Arrests

Special to the NNPA from the St. Louis American

The Target parking lot of the Buzz Westfall Shopping Center was filled with dozens and dozens of police vehicles and the area of West Florissant from Jennings to Ferguson was blocked off. Helicopters and tanks –as well as vehicles from a host of area departments – descended on West Florissant as looting and vandalism…

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Suppress Voting, Impeach Obama and Close HBCUs

Suppress Voting, Impeach Obama and Close HBCUs

By Peter Grear

Our campaign has sought to educate our communities to the point that they would organize and mobilize for a massive voter turnout for the November General Election and beyond. 

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Risky Situations Increase Women’s Anxiety, Hurt Their Performance Compared to Men

Risky Situations Increase Women’s Anxiety, Hurt Their Performance Compared to Men

Study author Susan R. Fisk

“On the surface, risky situations may not appear to be particularly disadvantageous to women, but these findings suggest otherwise,” 

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Voter Suppression: An Existential Threat to Democracy

Voter Suppression: An Existential Threat to Democracy

By Peter Grear

To properly understand where we are today, we must look to history, to Black Slavery.  Slavery has existed since the time of ancient civilizations and in its inception was based upon conquerors enslaving the conquered without regards to race.  

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Dorothy Buckhanan Wilson Installed as International President of Alpha Kappa Alpha Sorority, Incorporated

Dorothy Buckhanan Wilson Installed as International President of Alpha Kappa Alpha Sorority, Incorporated

Charlotte, NC (BlackPR.com)

Dorothy Buckhanan Wilson of Milwaukee, Wisconsin, a business executive, was installed as the 2014-2018 International President of Alpha Kappa Alpha Sorority, Incorporated (AKA)

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Nielsen Expands Communications Leadership Team with Key Media Relations Hire

Nielsen Expands Communications Leadership Team with Key Media Relations Hire

New York (BlackPR.com)

New York (BlackPR.com) -- Nielsen today announced that Andrew McCaskill has joined Nielsen as Senior Vice President, Corporate Communications. He will report to Chief Communications Officer Laura Nelson.

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Voter Suppression: It’s Mobilization Time

Voter Suppression: It’s Mobilization Time

Written by Peter Grear

With this article we will start detailing the ingredients of a revisable action plan that needs comments and revisions as we move toward the Tuesday, November 4, 2014 General Election.  

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Voter Suppression: NC Black Republican Advisory Board

Voter Suppression: NC Black Republican Advisory Board

Written by Peter Grear

Educate, Organize and Mobilize: I confess that I’m amazed. The Republican National Committee and the Republican Party of North Carolina announced last week that they have launched theNorth Carolina Black Advisory Board (BRAB) 

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$11.5 Million NIH Center Grant Funds Novel Cancer Stem Cell Research at the Methodist Hospital Research Institute

Written by Methodist Hospital, Houston on 19 February 2010.

The Methodist Hospital Research Institute was awarded an $11.5 million Center Grant by the National Institutes for Health (NIH) today to study the best way to attack deadly cancer stem cells to enhance treatments for breast cancer. Other members of the team include Baylor College of Medicine and the University of Texas Health Science Center at Houston.

“Targeting cancer stem cells, rather than cancer cells, is a completely new strategy for treating cancer,” said Dr. Stephen Wong, director of the Center for Bioengineering and Informatics at The Methodist Hospital Research Institute and principal investigator for the grant study. “By attacking the cancer stem cell, we hope to eliminate cancer’s ability to grow, recur or metastasize.”

The NIH grant will enable Wong’s team to model breast cancer stem cells – or see what they look like and how they act – using advanced genetic, imaging and computational modeling techniques. Wong said once the cells are modeled in the lab and in real environments, the team will be able to predict the behavior of cancer stem cells, enabling them to test drugs that might kill the cells or prevent the cells from duplicating and metastasizing.

Cancer stem cells, also called tumor initiating cells, have the ability to resist drugs, become cancer cells, and split into a cancer cell and another stem cell. Traditional cancer treatments use chemotherapy to kill cancer cells, but are not optimized to kill the stem cell.

“Targeting the cancer stem cell is the new horizon for cancer research,” Wong said. “We have put together a very strong team of top experts in the field. We’re able to combine that talent with the technology at our disposal at Methodist, Baylor, and UT. This is a formidable combination that has potential to achieve real breakthroughs in cancer research. It’s great to now have the backing of the NIH to help us move ahead.”

Wong’s team will build a modeling platform for investigation of breast cancer, with special emphasis on the role of tumor-initiating cells (TIC), or cancer stem cells. This platform will consist of two closely related components: biological experiments and mathematical computational modeling.
“Further, our systems biology approach will allow us to evaluate responses to experimental therapies that may restrain or kill tumor initiating cells in a manner not possible before,” Wong said.

The biological component will use new experimental imaging methods to identify, localize, purify and characterize the cancer stem cells. Tumor initiating cells cannot be seen using traditional imaging techniques. Methodist has invested in high resolution microcopy that can see at nanometer, rather than millimeter resolution, including a confocal laser scanning microscope, a Coherent anti-Stokes Raman Scattering (CARS) microscope, and an in vivo multi-photon laser scanning microscope. Additional protocols will be designed to understand the stem cell’s ability to metastasize, including spatial localization and movement, and specific changes in gene expression and cellular signaling of breast cancer stem cells.

For the mathematical modeling component, the team will develop bioinformatics and bio-imaging models to integrate and analyze the data generated from biological experiments. They will use the information obtained from data analysis and biological knowledge to build computer-based models to mimic the cells’ behavior and drug treatment response.

Besides providing a basic framework for understanding breast cancer stem cell evolution, the models will allow us to predict how the natural process of cancer development will play out in various circumstances, Wong said. The ultimate goal is better, more effective treatment for eliminating breast cancer in our patients.

For more information on The Methodist Hospital Research Institute, see www.methodistresearch.com. Follow us on Twitter at http://twitter.com/MethodistHosp and Facebook at http://www.facebook.com/methodisthospital.

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